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Weight gain is a common side effect of corticosteroid usage due to multiple factors. Corticosteroids can cause an increase in appetite, leading individuals to consume more calories than usual. Additionally, these medications can lead to fluid retention and alterations in metabolism that promote fat accumulation, particularly around the abdomen and face, resulting in a characteristic "moon face." The long-term use of corticosteroids can also interfere with the body's ability to process glucose, further contributing to changes in body weight and distribution of fat.

Understanding this side effect is essential for healthcare providers as it may affect the patient's adherence to treatment or overall quality of life. It’s important for nurses and healthcare professionals to monitor weight, educate patients on dietary choices, and encourage physical activity to mitigate some of the weight gain associated with corticosteroid therapy.