NCLEX Practice Test

Which factor increases the risk of adverse drug events in older adults taking multiple medications?

1. Increased drug clearance and decreased half-life

2. Polypharmacy and physiological changes associated with aging

3. Reduced frequency of doctor visits

4. Use of a single pharmacy for prescription medications

The correct answer is: Increased drug clearance and decreased half-life

Older adults taking multiple medications are at an increased risk of experiencing adverse drug events due to polypharmacy, which is the use of multiple medications at the same time. As people age, their bodies undergo physiological changes that can alter the way medications are absorbed, distributed, and eliminated. This can result in increased drug clearance and a decreased half-life, meaning the medication may not stay in the body long enough to be effective. Additionally, reduced frequency of doctor visits can result in a lack of monitoring and potential interactions between medications. Using a single pharmacy for prescription medications can help reduce the risk of adverse drug events by allowing for better coordination and oversight of all medications being taken. However, this alone does not increase the risk as significantly as the other options listed.